Lentiviral Gene Therapy Vectors: Challenges and Future Directions
نویسندگان
چکیده
Lentiviral vectors (LV) are efficient vehicles for gene transfer in mammalian cells due to their capacity to stably express a gene of interest in non-dividing and dividing cells. Their use has exponentially grown in the last years both in research and in gene therapy protocols, reaching 12% of the viral vector based clinical trials in 2011 [1]. This chapter reviews and discusses the state of the art on the production of HIV-1based lentiviral vectors.
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